12.3 Long-term follow up of patients with CINCA syndrome: efficacy and tolerability of Anakinra treatment
نویسندگان
چکیده
Address: 1Institute of Child Health IRCCS Burlo Garofolo, University of Trieste, Italy, 2II Division of Pediatrics, 'G. Gaslini' Institute for Children, Genoa, Italy, 3Department of Pediatrics, Federico II Hospital, Naples, 4Department of Pediatric Sciences, Catholic University of Sacred Heart, Rome, Italy, 5Department of Rheumatology and Clinical Immunology, Brescia, Italy and 6Pediatric Rheumatology Unit, Department of Pediatrics, Padova, Italy * Corresponding author
منابع مشابه
Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap)
Cryopyrin-associated periodic syndromes (CAPS) are a group of inherited inflammatory disorders consisting of familial cold-induced autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID; also known as chronic infantile neurologic, cutaneous, articular [CINCA] syndrome). These rare disorders are associated with heterozygous mutat...
متن کاملClinical and genetic characterization of Italian patients affected by CINCA syndrome.
OBJECTIVE We report the experience of the Italian Registry of patients affected by chronic infantile neurological, cutaneous, articular (CINCA) syndrome. The clinical and genetic features of 12 unrelated Italian patients with CINCA syndrome are described, focusing on the possible influence of the presence of CIAS1/cryopyrin mutations on the phenotype of the disease and on its prognosis. METHO...
متن کاملEFFICACY AND SAFE TY OF LAMOTRIGINE AS A DD-ON THE RAPY IN 132 CHILDREN AND ADULT IRANIAN PATIENTS WITH TREATMENT-RESISTANT EPILEPSY
This study was initiated to evaluate the long-term safety, tolerability and efficacy of seizure control of lamotrigine (LTG) in children and adult patients with partial seizures (PS) with or without secondary generalized seizure. A total of 132 patients (age 5-41 years) with treatment-resistant epilepsy received LTG as addon therapy for up to four years. Overall, patients were treated with ...
متن کاملLong term follow up of recurrent uterine cervical cancer: A Case Report
Background and Aim: Carcinoma of the uterine cervix is a significant cause of mortality because of malignancy in women. Radiotherapy is a major treatment modality for invasive cervical cancer with good treatment outcome in early-stage patients. However, substantial treatment failures still occur in the advanced-stage patients. In this case report a long term follow up of a 58 years old woman wi...
متن کاملPW03-020 – A decade of ANTI-IL-1 therpay for CAPS in the UK
Results Of 82 patients with clinical CAPS a pathogenic sequence variant (PSV) was detected in 77 (94%); 17 PSVs were identified, the commonest were R260W (27%), A439V (23%), T348M (17%), V198M (5%). 5 patients had no PSV detected on Sanger sequencing: 3 children with CINCA and 2 patients with adult onset clinical MWS. 90% were white, 8.5% South Asian and 1% African. 46 (56%) gave a positive fam...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2008